Shabsigh, R. (2005), Testosterone Therapy in Erectile Dysfunction and Hypogonadism. Journal of Sexual Medicine, 2: 785–792. doi: 10.1111/j.1743-6109.2005.00139.x
BUMSIK HONG, YOUNG HWAN JI, JUN HYUK HONG, K.I. YEUL NAM, TAI YOUNG AHN. A Double-Blind Crossover Study Evaluating the Efficacy of Korean Red Ginseng in Patients With Erectile Dysfunction: A Preliminary Report. The Journal of Urology. Volume 168, Issue 5, November 2002, Pages 2070–2073
Chen, Wollman, Chernichovsky, Iaina, Sofer and Matzkin (1999), Effect of oral administration of high-dose nitric oxide donor l-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. BJU International, 83: 269–273. doi: 10.1046/j.1464-410x.1999.00906.x
http://www.drugwatch.com/testosterone/heart-attack/ One testosterone study published in January 2014 found increased heart attack risk in men who used testosterone. The risk did not only apply to older men. But men young than 65 with pre-existing heart disease had “a twofold increase in risk of nonfatal heart attack shortly after initiation of testosterone therapy,” according to the study.
Finkle WD, Greenland S, Ridgeway GK, Adams JL, Frasco MA, et al. (2014) Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men. PLoS ONE 9(1): e85805. doi: 10.1371/journal.pone.0085805
Side-effect profile of sildenafil citrate (Viagra) in clinical practice.Moreira, Sergio G et al. Urology , Volume 56 , Issue 3 , 474 – 476
MAHAJAN SK, ABBASI AA, PRASAD AS, RABBANI P, BRIGGS WA, McDONALD FD. Effect of Oral Zinc Therapy on Gonadal Function in Hemodialysis Patients: A Double-Blind Study. Ann Intern Med. 1982;97:357-361. doi:10.7326/0003-4819-97-3-357
There is a lack of data suggesting the efficacy of testosterone therapy in older men who do not meet the clinical definition of hypogonadism. Specifically, there is no convincing evidence that testosterone therapy is either effective or safe for older men, unless frank androgen deficiency is evident [Handelsman DJ, Zajac JD. Androgen deficiency and replacement therapy in men. Med J Aust 2004;180: 529–35]. The Institute of Medicine (IOM) has recommended additional clinical research focusing on the benefits of testosterone therapy in older men as compared with placebo controls, followed by larger-scale and longer-term trials to assess risks and benefits [Liverman CT, Blazer DG, editors. Testosterone and aging: Clinical research directions. Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy. Washington, DC: The National Academies Press; 2004:1–9]. Origin: Shabsigh, R. (2005), Testosterone Therapy in Erectile Dysfunction and Hypogonadism. Journal of Sexual Medicine, 2: 785–792. doi: 10.1111/j.1743-6109.2005.00139.x
After suffering heart attacks, strokes and other heart-related events after receiving testosterone therapy, men are filing lawsuits against the maker of Androgel and other Low-T product manufacturers. A federal multidistrict litigation (MDL) is established in Illinois. In March 2015, the agency issued a safety warning that testosterone drugs may increase the risk of stroke, heart attack, and death in men taking FDA-approved testosterone products. Over 1,000 lawsuits filed by men who say testosterone drugs caused their cardiovascular problems are pending in federal court. Origin: https://www.drugwatch.com/testosterone/lawsuit/
